If you are still experiencing issues, ensure your Windows is fully updated and that you have no other virtualization software running in the background (like Docker, VMWare Workstation, or VirtualBox) that might be reserving system resources.
If none of the software-level fixes have worked, the problem might be at the hardware level. Enter your computer’s BIOS/UEFI settings (usually by pressing Delete , F2 , or F12 during startup) and look for an option like or AMD-V . Set it to Disabled . Once you have disabled virtualization, you should be able to run Dead Space 3 without any issues.
Even more confusing? You aren't running a virtual machine. You’re on a standard Windows 10 or Windows 11 gaming PC, not VMware, VirtualBox, or Hyper-V. If you are still experiencing issues, ensure your
Boot into Windows and try the game. If this works, you have identified that your motherboard’s firmware is triggering the DRM.
The gaming community created a specific patcher for this exact error because the DRM is so troublesome. Set it to Disabled
The issue is typically a generated by the game’s compatibility checks. It frequently occurs because of modern Windows features that use virtualization technology at the system level:
This is the most common fix for this specific error. You aren't running a virtual machine
Top Solutions to Fix "Application Cannot Run Under a Virtual Machine"
Note: If you are uncomfortable leaving this feature off for security reasons, you can turn it back on after you are done playing the game, though you will have to repeat this process every time you want to play.
Disabling virtualization will break any software that requires it (WSL, Android Studio emulators, VMware, etc.).