Newer versions of iTunes include updated drivers that patched the specific communication vulnerabilities p0sixspwn used to "talk" to the device's bootloader. The False Positive:

Once you have resolved the iTunes requirement error, follow these steps to perform the untethered jailbreak:

Re-install Apple Mobile Device Support.

Additional mistakes include:

Click Apply, then OK, and run p0sixspwn.

What your computer runs (Windows 11, Mac M1, etc.)?

Method 1: Install the iTunes 12.1.1 "For Older Video Cards" Driver (Windows - Recommended)